Two sample MR report
HLA-DQB1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 35 | 0.2044754 | 0.1289790 | 0.1224268 |
| Weighted median | 35 | -0.1337744 | 0.0270346 | 0.0000007 |
| Inverse variance weighted | 35 | -0.1207869 | 0.0192508 | 0.0000000 |
| Simple mode | 35 | -0.2018764 | 0.0543595 | 0.0007295 |
| Weighted mode | 35 | -0.1385629 | 0.0476662 | 0.0063825 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 26.99758 | 33 | 0.7597837 |
| Inverse variance weighted | 33.50208 | 34 | 0.4918719 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1012838 | 0.039713 | 0.0155858 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006093 | 0 | TRUE | 0.0196673 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
